Enhanced sampling molecular dynamics to understand force response in peptide tension sensors

Abstract

Mechanical forces are ubiquitous in diverse cellular processes, such as cell division, motility, and adhesion. “Mechanoresponsive” proteins and peptides are present which respond to applied forces and change in structure and function to facilitate these cellular processes. Experimental techniques such as single-force spectroscopy have been invaluable in studying protein mechanics, including force-extension curves. Scientists have also developed Tension Sensor Modules which have been used to determine the magnitude and location of forces inside cells.