Abstract
gene copy number was determined by means of a TaqMan real-time PCR assay. Results: Significantly higher frequencies of the AA genotype of G-20A and the AA genotype of G-52A were observed among the patients with severe acute pancreatitis as compared with the healthy controls (38% vs 20%, and 41% vs 18% respectively). The GG protective genotype of C-44G SNP was much less frequent (1%) among the patients than among the controls (9%). A higher frequency of a lower (<4) copy number of the DEFB4 gene was observed in the patients with severe acute pancreatitis than in the healthy controls (62% vs 24% respectively). Conclusions: The genetic variations in the genes encoding the human b-defensin 1 and that of human b-defensin 2 may be associated with the risk of severe acute pancreatitis.
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