Abstract
Vascular abnormalities in the ovary cause ovarian dysfunction due to a microenvironment of barren ovarian tissues. Platelet-derived growth factor signaling pathway in vascular structure and their function are critical factor in follicular development and ovarian function. In previous reports, we demonstrated placenta-derived mesenchymal stem cells (PD-MSCs) restore ovarian function via antioxidants effect. However, there is still unclear the therapeutic mechanism between ovarian function and vascular remodeling.
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