Abstract
The effect of an infection in mice with a murin hepatitis virus Buescher type (MHVB) on the liver microsomal drug metabolizing enzymes is investigated, alone, as well as in combination with phenobarbital pretreatment. A diphasic effect of the infection with MHVB on the microsomal drug-metabolizing enzymes is observed: the enzyme activity is slightly increased 12 hr after the infection and is markedly depressed 48–60 hr after. The effect of phenobarbital pretreatment on the microsomal drug metabolizing enzymes is markedly enhanced in mice infected 12 or 24 hr previously. These results suggest that the condition of stimulated biosynthesis of protein and RNA in the liver of infected mice may enhance the effect of phenobarbital.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
