Abstract
Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion time of the prepared tablets were found to be dependent on the type and composition of the buccoadhesive materials used. The effect of bile salts on the permeation was studied through porcine buccal mucosa and it was found that out of three bile salts incorporated (sodium glycholate, sodium taurocholate, and sodium deoxycholate), sodium glycholate enhanced the permeation rate of prochlorperazine maleate by an enhancement factor of 1.37.
Highlights
The pharmaceutical world is full of research and discoveries in many novel and advanced drug delivery systems for therapeutic use, the popularity of oral dosage forms, tablets, have not been eclipsed
Among the formulations containing bile salts, a remarkable increase in the flux of prochlorperazine maleate through porcine buccal mucosa was observed in formulations containing sodium glycocholate, followed by sodium taurocholate
There was no considerable increase in the flux in the presence of sodium deoxycholate
Summary
The pharmaceutical world is full of research and discoveries in many novel and advanced drug delivery systems for therapeutic use, the popularity of oral dosage forms, tablets, have not been eclipsed This is due to its various advantages and. The buccal route is a subject of growing interest because of its numerous advantages [1, 2] It is well-known that the absorption of therapeutic compounds from the oral mucosa provides direct entry of the drug into systemic circulation, avoiding first-pass hepatic metabolism and gastrointestinal drug degradation and improves bioavailability. It is robust, accessible, and shows high patient compliance [3]. It is safe since the device can be administered and even removed from the site of application, stopping the input of drug whenever desired
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