Abstract
Liver mitochondria from genetically obese ( ob/ ob) mice exhibited a higher rate of oxidation than those from normal littermate controls when β-hydroxybutyrate, succinate, or ascorbate plus N,N,N′,N′-tetramethyl- p-phenylene diamine were employed as substrates. Succinate and β-hydroxybutyrate dehydrogenase activities showed a similar increase. No such difference, however, was observed with glutamate as substrate. The intramitochondrial concentrations of all the cytochromes were increased significantly, as was the total ATPase activity, while the ADP O ratios were identical in mitochondria from the two kinds of mice.
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