Enhanced oxidative and carbonyl stress predicts salt sensitivity in obese young adults

Abstract

BackgroundMethylglyoxal (MGO), a carbonyl substance, is increased in CKD patients and can induce salt sensitive hypertension and insulin resistance together with enhanced oxidative stress in a rat model. The present study determined whether carbonyl/oxidative stress is enhanced in obese young adults and would associate with salt sensitivity.MethodsYoung adult students (2335students, male:1794, female:541, age:18to28)were enrolled for the study. Daily Na excretion (UNa, as a indicator of Na intake), albumin (UAE, as a marker of CKD), TBARS (U‐TBARS, as a marker of oxidative stress) and MGO (U‐MGO, as a marker of carbonyl stress) was analyzed. Correlations were determined among the parameters in the health checkup.ResultsAlthough, SBP, U‐TBARS, U‐MGO and UNa were increased with higher BMI or AC in male students, SBP was increased without increase in U‐TBARS and UNa in high BMI or AC female students. U‐TBARS and U‐MGO had a positive correlation with UNa, and UAE significantly increased with BMI of 30 and above compared to under 30 in either sex. Finally, SBP correlated with BMI of 30 and above in male students while no correlation was observed in those under 30.ConclusionThese results indicate that obese has a higher risk of salt sensitive hypertension and CKD in young adults which can be predicted by carbonyl/oxidative stress. Supported by the Grants‐in‐Aid from the Min. of ECSST of Japan (No.20590970)