Abstract
Objectives: The aim of this study was to design and formulate mixed polymer-lipid nanoparticles (PLNs) for the delivery of ibuprofen. Methods: The mixed PLNs were prepared by a single modified emulsification solvent evaporation method. Key findings: Core-shell-shaped mixed PLNs were successfully prepared, with sizes in thenano range (193.3±0.70 to 795.8±0.70nm) and ζ potential (-26.8±0.45 to -42.8±0.30mV). Entrapment efficiencyranged from 80.3to 93.6%. Conclusions: Pharmacokinetic parameters showed great improvement in Cmax and Tmax of ibuprofenfrom the formulationPLNs8compared with the respective Brufen® and pure drugs, indicating improvement in bioavailability of the drug.
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