Abstract
Purpose The effect of cold low-pressure plasma treatment on neovascularization of a dermis substitute was evaluated in a mouse model. Material and methods Collagen-elastin matrices (Matriderm ®) were used as scaffolds. Low-pressure argon/hydrogene plasma-treated scaffolds were transplanted into the dorsal skinfold chambers of balb/c mice (group 1, n = 10). Untreated scaffolds served as controls (group 2, n = 10). Intravital fluorescence microscopy was performed within the border zone of the scaffolds on days 1, 5 and 10. Functional vessel density (FVD), vessel diameter, intervascular distance, microvascular permeability, and leukocyte-endothelium interaction were analyzed. Results An increase of FVD associated with a reduction of the intervascular distance was observed. Statistical analysis revealed that the functional vessel density in the border zone of the scaffolds was significantly enhanced in the plasma-treated group compared to controls. For group 1, an increase of FVD from 282 ± 8 cm/cm 2 on days 5 to 315 ± 8 cm/cm 2 on day 10 was observed. Whereas values of 254 ± 7 cm/cm 2 on day 5 and 275 ± 13 cm/cm 2 on day 10 have resulted in group 2 (mean ± S.E.M., Student's t-test, p < 0.05). Conclusion The surface treatment by cold low-pressure plasma intensifies the angiogenesis and accelerates the neovascularization of collagen-elastin matrix.
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