Enhanced Nanohydroxyapatite Formation Using a Hydrolyzed Gelatin

Ding Ding,Yaqin Huang,Weijie Zhang,Tengfei Yu,Wei Liu

doi:10.1155/2015/628405

Abstract

Hydroxyapatite (HAP) nanoparticles were synthesized at room temperature using hydrolyzed gelatin (HG) as an additive. The crystallinity of HAP particles can be effectively controlled by adjusting the concentration of HG additive and the pH value of reaction system. The synthesized product was analyzed by Fourier transform infrared (FTIR) spectrometer, energy dispersive spectrometer (EDS), X-ray diffractometry (XRD), and transmission electron microscope (TEM). Meanwhile, it was proved that, with HG additive, HAP can be prepared with the calcium-phosphorus ratio of not only 1.67 but also 1.50. Conventionally, HAP particles need to be synthesized at high temperature with iCa/P = 1.67. Therefore, we believe that this study provides a novel strategy for the preparation of nano-HAP.

Highlights

Hydroxyapatite (HAP) has attracted much attention recently in the field of bioengineering [1], especially as a bone substitute material due to its biological compatibility and bone conduction
Researchers found that HAP crystal growth depended greatly on the properties of the starting solution, and the morphology of the HAP crystals could be affected by the initial calcium to phosphorus (Ca/P) ratio
Pure HAP particles can be synthesized at the higher temperature with initial Ca/P ratio (iCa/P) = 1.67 [8]

Summary

Introduction

Hydroxyapatite (HAP) has attracted much attention recently in the field of bioengineering [1], especially as a bone substitute material due to its biological compatibility and bone conduction. Pure HAP particles can be synthesized at the higher temperature with iCa/P = 1.67 [8] Compared to these artificially synthesized particles, HAP particles obtained from natural bone exhibit better mechanical and biological properties [9]. The functional groups of organic natural polymer can interact with calcium ions and promote nucleation via molecular recognition. Collagen is a kind of nature polymer This inspired us to design a new way to prepare the nano-HAP using the hydrolyzed gelatin (HG) as a multifunctional additive. Groups [7, 11], in HG molecules can interact with calcium ions This kind of interactions may promote the formation of HAP and the mediation of the morphology in nano-HAP particles. This report provides a detailed description of this novel nano-HAP synthesis using HG as a functional additive

Experimental

Results and Discussion

Conclusion