Abstract
The aging of skin stem cells is always attractive and highly relevant to our daily lives. Hair graying, mainly caused bymelanocyte stem cell (MeSC) aging, is a severe problem for many people. Previous studies have pointed out that DNAdamage is a significant reason for MeSC aging, and the enhanced mTORC1 pathway leads to DNA damage. Here,experiments in vivo and in vitro were designed to verify that enhanced mTORC1 pathway leads to melanocyte stemcell aging through the cause of DNA damage. The research could have the significance of discovering possible reasonsfor hair graying and providing some new ideas in treating this abnormal divergence and other diseases relevant to cellaging.
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