Abstract
Abstract The transfer process of various acidic drugs from water into chloroform containing phospholipids has been examined using a nonemulsifying system. The ionized forms of the drugs which have little lipid solubility show a marked increase in transfer to the chloroform phase containing lecithin at the physiological pH of the small intestine. The pH-profiles of salicylic acid, p-aminobenzoic acid and sulphisoxazole transfer are in good agreement with available in situ absorption data. These results suggest a role for phospholipids in the intestinal absorption of ionized acidic drugs which has not been clearly apparent with pH-partition hypothesis alone.
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