Enhanced inhibitory effect of prostate cancer research with toughening groups-curcumin monoester

Abstract

Objective Discussion of the toughening group-curcumin monoester (tert-butoxycarbonyl-phenylalanine ester curcumin monoester) representing curcumin more enhanced the feasibility about inhibition of human prostate cancer in vivo.Methods After establishment of animal portability models of human prostate cancer of PC-3 cell line with 40 nude mice,which were selected based on tumor volume close to 36 and randomly divided into three groups including A group with injection of normal saline),group B with injection of curcumin and group C with injection of tert-buto-xycarbonyl group-the phenylalanine ester curcumin monoesters with every other day,a total of 15 times.Four weeks later,nudemice were treated to sacrificing.stripping tumor were weighed and inhibitory rate were calculated.HE staining of tumor tissue and TdT-mediated dUTP nick end labeling (TUNEL) assay were detected.Results The animal models of human prostate cancer portability tumor was successfully established.A,B,C group inhibition rates were 0％,21.76％ and 55.18％ respectively.The difference between the groups were statistically significant (P ＜ 0.05).In TUNEL assay,A,B and C apoptotic index were (4.2 ± 1.3) ％,(26.6 ± 7.8) ％ and (49.2-± 8.6) ％,differences among the groups were statistically significant (P ＜ 0.05).Conclusion Inhibiting effect on human prostate cancer xenograft in vivo with tert-butoxycarbonyl pheny lalan-ine ester curcumin monoester on more significantly higher than with pure curcumin. Key words: Prostate cancer; Tert-butoxycarbonyl group-phenylalanine ester curcumin monoester; Model,animal