Abstract
Drug-resistant bacterial infections exhibit a major threat to public health. Thus, exploring a novel antibacterial with efficient inhibition is urgently needed. Herein, this paper describes three types of MSNs (MSNs-FC2-R1, MSNs-FC2-R0.75, MSNs-FC2-R0.5) with controllable pore size (4–6 nm) and particle size (30–90 nm) that were successfully prepared. The MSNs were loaded with tetracycline hydrochloride (TCH) for effective inhibition of Escherichia coli (ATCC25922) and TCH-resistant Escherichia coli (MQ776). Results showed that the loading capacity of TCH in three types of MSNs was as high as over 500 mg/g, and the cumulative release was less than 33% in 60 h. The inhibitory rate of MSNs-FC2-R0.5 loaded with TCH against E. coli and drug-resistant E. coli reached 99.9% and 92.9% at the concentration of MIC, respectively, compared with the other two types of MSNs or free TCH. Modified MSNs in our study showed a great application for long-term bacterial growth inhibition.
Highlights
Molecules 2022, 27, 1218. https://The number of drug-resistant bacteria has increased exponentially over the past few years due to the abuse of antibiotics in agriculture and human health services, which poses big challenges to disease prevention and control [1]
It was noted that three types of Mesoporous silica nanoparticles (MSNs) were spherical silica nanoparticles with large-pore dendritic structures
Mesoporous silica nanoparticles with adjustable pore size were prepared by tuning the molar ratios (R) of fluorocarbon anions to Cetyltrimethylammonium bromide (CTAB) based on a previous report with some modifications [14]
Summary
The number of drug-resistant bacteria has increased exponentially over the past few years due to the abuse of antibiotics in agriculture and human health services, which poses big challenges to disease prevention and control [1]. Developing new bactericides that can combat bacterial and drug-resistant bacteria with long-term efficiency is a great emergency. Mesoporous silica nanoparticles (MSNs) are inorganic silica nanocarrier materials with tunable pore sizes from 2 to 50 nm. The excellent mesoporous structure with an adjustable pore size facilitates effective drug loading and controlled release. The modified surface of MSNs enhances the drug’s therapeutic efficacy and reduces toxicity, which has been approved by the US Food and Drug Administration. The prominent characteristics of MSNs provide a great opportunity for antibacterial therapy
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