Enhanced In Vitro Cytotoxicity and In Vivo Nursing Care of Gastric Cancer Cells by Nanoparticles Bearing Platinum (IV) Prodrug of Cisplatin

Abstract

Gastric cancer is known as the fourth most common cancer and the second main cause of cancer-related deaths. Finding a suitable system of drug delivery for effective treatment in gastric cancer chemotherapy has been of great value in recent years. Platinum-based drugs are among the most popular drugs for solid tumors chemotherapeutic agents in the clinic. However, severe side effects such as neurotoxicity and etc. It limits the use of extreme doses of the drug. To overcome these issues Pt(IV) prodrugs and nanocarriers as the platinum delivery systems might represent the next generation of platinum-based drugs. The present assay aimed to develop a nanoparticles-based Pt(IV) prodrug delivery system to enhance the In Vitro cytotoxicity and In Vivo nursing care of gastric cancer. The characterizations depicted that the synthesized formulation exhibited beneficial physicochemical properties. The biological assays showed that the synthesized formulation exhibited a sustained drug release profile. Moreover, the application of the synthesized formulation enhanced the In Vitro cytotoxicity and In Vivo nursing care of gastric cancer. The results suggest that the developed formulation is one of the most important candidates for nursing care is to treat this kind of diseases.