Abstract
This research focused on a dissolved oxygen (DO)-shifting strategy to enhance the production of hyaluronic acid (HA) by Streptococcus zooepidemicus. In this strategy, DO was controlled at above 10 ± 1% during 0–8 h and at 5 ± 0.5% during 8–18 h. The DO-shifting strategy increased the consistency index and oxygen mass transfer coefficient and decreased the flow behavior index n. With the proposed DO-shifting strategy, HA production increased from 5.0 ± 0.1 g/L to 6.3 ± 0.1 g/L. The enhanced HA production was attributed to the alleviation of carbon and energy competition between cell growth and HA synthesis.
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