Abstract
Enhanced haemagglutination and phytochemical evaluation suggest significant presence of glycoproteins (Lectins) in semi-purified fractions of eastern Nigeria Mistletoe, Loranthus micranthus Linn.
Highlights
Glycoproteins from European and Korean mistletoes have been demonstrated to exhibit potent immunomodulatory, mucosal adjuvanting, mitogenic nitric oxide induction, apoptotic, antitumor and Toll-Like Receptor-4 (TLR4)-mediated activation of mouse macrophages activities
The Mistletoe lectin (ML) is composed of A and B chains linked by a disulfide bond
We have studied the eastern Nigeria mistletoe Loranthus micranthus Linn) and isolated immunomodulatory and antioxidant compounds [8] that showed very potent mitogenic activity on mice splenocytes and increased expression of the CD69 molecule [9]
Summary
Glycoproteins (lectins) from European and Korean mistletoes have been demonstrated to exhibit potent immunomodulatory, mucosal (cellular and humoral) adjuvanting, mitogenic nitric oxide induction, apoptotic, antitumor and Toll-Like Receptor-4 (TLR4)-mediated activation of mouse macrophages activities. Omeje EO (2015) Enhanced haemagglutination and phytochemical evaluation suggest significant presence of glycoproteins (Lectins) in semi-purified fractions of eastern Nigeria Mistletoe, Loranthus micranthus Linn strong molecular tie with immunology as much as inflammatory pathways, endocrine system and even several other intricate signalling pathways [10] This observation (the stimulatory effect of CD69 molecule), sharply contrasted an observed cytotoxic action of direct injection of crude Nigerian mistletoe extract into non-melanoma nodular tumor in mice (unpublished data) in addition to the presence of proteins and carbohydrates in the crude extracts and fractions. The Nigerian mistletoe contains notable cytotoxic contents which possibly are glyco-proteins (lectins) as have been reported for similar species from other parts of the world With all these well established data on bioactive lectins of both European and Korean mistletoes, and the established biological activities of the eastern Nigeria mistletoes, it becomes imperative to study the Nigerian mistletoes in the context of the potential biological functions of its probable lectins.
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