Abstract
Core-shell nanostructures of Mn2O3@SiO2, Mn2O3@amino-functionalized silica, Mn2O3@vinyl-functionalized silica, and Mn2O3@allyl-functionalized silica were synthesized using the hydrolysis of the respective organosilane precursor over Mn2O3 nanoparticles dispersed using colloidal solutions of Tergitol and cyclohexane. The synthetic methodology used is an improvement over the commonly used post-grafting or co-condensation method as it ensures a high density of functional groups over the core-shell nanostructures. The high density of functional groups can be useful in immobilization of biomolecules and drugs and thus can be used in targeted drug delivery. The high density of functional groups can be used for extraction of elements present in trace amounts. These functionalized core-shell nanostructures were characterized using TEM, IR, and zeta potential studies. The zeta potential study shows that the hydrolysis of organosilane to form the shell results in more number of functional groups on it as compared to the shell formed using post-grafting method. The amino-functionalized core-shell nanostructures were used for the immobilization of glucose and L-methionine and were characterized by zeta potential studies.
Highlights
Surface modification is an integrated and crucial part of material processing and is the basis for the functionality of the material
To the best of our knowledge there has been only one report on the formation of amino-functionalized silica shell over ultrasmall superparamagnetic iron oxide particles (USPIO) using the hydrolysis of the organosilane
In this study we show the ability of these nanostructures to immobilize glucose and L-methionine
Summary
Surface modification is an integrated and crucial part of material processing and is the basis for the functionality of the material. To the best of our knowledge there has been only one report on the formation of amino-functionalized silica shell over ultrasmall superparamagnetic iron oxide particles (USPIO) using the hydrolysis of the organosilane. These particles were coated with silica, (3-aminopropyl) trimethoxysilane (3-APTMS), and [N-(2-aminoethyl)-3aminopropyl]trimethoxysilane (AEAPTMS), and their ability to label immortalize progenitor cells for magnetic resonance imaging (MRI) was compared. The high density of functional groups will ensure an increase in the number biomolecules or drugs that can be immobilized on these nanostructures For this we have carried out a case study using glucose and L-methionine and have shown that the functionalized core-shell nanostructures can be used to immobilize biomolecules
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