Abstract
Line 413 early-onset, genetically homozygous dystrophic chickens were given in two separate trials twice-daily i.p. injections of indomethacin and diphenylhydantoin, pharmacological antagonists of calcium flux. An additional trial consisted of treatment with prednisolone, an antiinflammatory corticosteroid. Chemotherapy in each case significantly prolonged the righting ability of the treated dystrophic chickens, as measured by a periodic, standardized flip test for functional ability. The characteristically elevated plasma creatine phosphokinase activities were not markedly affected by any of the treatments. Small decreases in the abnormal blood serotonin concentrations were found in each trial. Intracellular calcium concentrations in the muscle, but not in the blood, of the dystrophic chickens (mean, 15.4 ± 2.7 μmol calcium/g noncollagen protein) were found to be significantly higher ( P < 0.02) than those in the corresponding normal chickens (6.8 ± 0.2 μmol/g). This finding may partially account for the enhancement in functional ability seen in dystrophic chickens receiving drugs inhibitory to calcium flux.
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