Abstract
A compound disinfectant, which consisted of didecyldimethylammonium chloride (DDAC), ortho-dichlorobenzene (1,2-dichlorobenzene, ODB), and chlorocresol (4-chloro-3-methylphenol, CC), and its component chemicals were individually tested for effectiveness against bovine herpes virus type 1 (BHV-1). DDAC, DDAC+ODB, DDAC+CC, and DDAC+ODB+CC showed effectiveness against BHV-1 at room temperature. However, ODB, CC, and ODB+CC showed no virucidal effects. The effects of all disinfectants tested were decreased at low temperature. DDAC showed disinfectant effects at a dilution of 1/800 and DDAC+ODB, DDAC+CC, and DDAC+ODB+CC at dilutions of 1/800 and 1/1600 at low temperature in the presence of 2% fetal bovine serum (FBS) but ODB, CC, and ODB+CC showed no virucidal effects. At low temperature and in the presence of 10% FBS, DDAC, DDAC+ODB, and DDAC+CC showed disinfectant effects at dilutions of 1/800, whereas ODB, CC, and ODB+CC showed no virucidal effects. DDAC+ ODB+CC was more effective (at 1/800 and 1/1600) than the other disinfectants under these conditions. In conclusion, a combination of three disinfectant components (DDAC+ODB+CC), enhanced the disinfectant effects at low temperature and in organic matter contamination.
Highlights
Disinfection is the primary method that prevents the spread of infectious diseases
A compound disinfectant, which consisted of didecyldimethylammonium chloride (DDAC), ortho-dichlorobenzene (1,2-dichlorobenzene, ODB), and chlorocresol (4-chloro-3-methylphenol, CC), and its component chemicals were individually tested for effectiveness against bovine herpes virus type 1 (BHV-1)
We investigate whether a compound disinfectant is more effective than its component chemicals against bovine herpes virus type 1 (BHV-1), which causes respiratory disease in bovines during winter
Summary
Not all disinfectants are effective against all pathogens; it is important to select an appropriate disinfectant [1,2,3]. Phenolic compounds are the oldest established active disinfectant substances and still play a major role in today’s arsenal of disinfectants [2,3]. These compounds induce membrane damage and have a wide spectrum of activity against bacteria, enveloped viruses, fungi, and mycobacteria [2,4]. We investigate whether a compound disinfectant is more effective than its component chemicals against bovine herpes virus type 1 (BHV-1), which causes respiratory disease in bovines during winter
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