Abstract
Magnesium (Mg) and its alloys have been regarded as one of the most promising biodegradable implant materials, whereas the rapid degradation rate and potential cytotoxicity hinder their clinic applications. In order to improve the biocompatibility and biocorrosion resistance of Mg alloy, a composite coating which composed of calcium phosphate (CaP) and collagen (Col) was successfully fabricated on the surface by chemical conversion and dip-coating methods. The chemical compositions, surface morphologies and corrosion resistance of the CaP/Col coating were investigated using X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), electrochemical and immersion test. Results revealed that the collagen coating efficiently sealed the cracks and pores of CaP coating, and significantly enhanced the corrosion resistance. Furthermore, the composition of the CaP/Col coating was similar to that of bone, which can more effectively promote the adhesion, proliferation and differentiation of osteoblasts, showing excellent biocompatibility and biosafety. These observations indicated that the CaP/Col coating could protect Mg alloy from fast degradation, greatly enhance biocompatibility and osteoinductivity, and thus could be promising for orthopedic implant applications.
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