Abstract
The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2](2-) (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, also achieved using PEI-coated AuNPs.
Highlights
The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2]2− (1) forms outer-sphere coordination interactions with non-toxic low molecular weights (MW) PEI, which results in enhanced cancer cell killing, achieved using PEI-coated AuNPs
Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines†
The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2]2− (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, achieved using PEI-coated AuNPs
Summary
Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines† The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2]2− (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, achieved using PEI-coated AuNPs. Cisplatin stands as one of the most commonly used and few chemotherapeutic agents with broad efficacy for cancer treatment.[1] Despite its clinical success there are several limitations to its use, including limited selectivity, development of side effects and resistance mechanisms.
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