Abstract
Much attention has recently been directed toward natural cytolysis and its augmentation. Interferon is a well-documented natural killing enhancer, albeit its mechanism of modulation is still controversial. Utilizing a fluorochrome-labeled binding assay in a batch system correlated with a chromium release lytic assay, we examined binding and NK function against the NK susceptible target K562. We found not only percentage cytolysis increased after incubation with interferon, but also percentage effector binding cells increased substantially. Thus, we conclude that effector incubation with interferon increases the number of NK susceptible target binding cells.
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