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Abstract
Under the appropriate in vitro test conditions, intactE. coli strain K-12 was shown to be susceptible to the effects of platelet-derived β-lysin preparations. Enhanced β-lysin activity induced by variations in the initial log phase growth temperatures ofE. coli is presumed to be due to alterations in outer membrane fluidity. Treatment ofE. coli with ethylenediaminetetraacetate (EDTA) or ethyleneglycoltetraacetate (EGTA) appeared to promote enhanced outer membrane permeability, which was reflected by an increase in the susceptibility of EDTA- and EGTA-treated cells to platelet β-lysin. Restoration of outer membrane integrity was apparent when EDTA- or EGTA-treated cells were incubated in the presence of either CaCl2 or MgCL2 prior to β-lysin treatment and subsequently showed resistance to β-lysin bactericidal activity.
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