Abstract
AbstractSeries of organoruthenium complexes and their nano biocomposites were prepared and analyzed by various spectral analyzed techniques like infrared (IR), UV–Vis,1H‐nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) spectroscopy, and high‐resolution mass spectrometry (HR‐MS). The redox properties of organoruthenium complexes were studied by cyclic voltammogram. UV–Vis and fluorescence spectroscopy employed to study the binding affinity of Ru (III) complexes with CT‐DNA and serum albumin (bovine serum albumin [BSA]). From the Ksv and Kb values, the interaction between BSA and organoruthenium complexes confirmed the mechanism of binding as static quenching. Scanning electron microscopic (SEM) studies validated the formation of new hybrid organometallic proteomics (P1–P4), while binding of the complexes with protein (BSA). A comparative cytotoxic profile of organoruthenium complexes and their nano biocomposites were evaluated. The results revealed the higher anticancer activity of nano biocomposites than their parent organoruthenium derivatives.
Published Version
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