Abstract
Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute intoxication rats. The ethanol and acetaldehyde levels of serum were lower in rats treated with CA than those who only treated ethanol. The activities of alcohol dehydrogenase and acetaldehyde dehydrogenase also recovered faster in the CA group than only-ethanol group. The transaminase levels (AST, ALT) in the CA group were significantly lower than only-ethanol group. In addition, Hepatic histological analyses and stomach wall were demonstrated that the CA-treated group recovered faster than only-ethanol group. With regard to most characteristics, we found that CA had dose-dependent effects. At high concentrations of CA, there were no differences in the tested parameters compared to those of normal rats. These findings indicate that CA reduces the serum alcohol concentration and some of the hepatic damage caused by alcohol intoxication.
Highlights
Alcohol has long been a favorite beverage across the world
Alcohol metabolism To investigate the effect of CA on alcohol metabolism, we measured the serum ethanol and acetaldehyde levels
The increase in acetaldehyde level was significantly lower in the CA and PC groups than it was in the Controls
Summary
Alcohol has long been a favorite beverage across the world. Drinking in moderation can help with blood circulation. Large doses of alcohol at one time can cause acute intoxication, acute alcoholic hangover, nausea, vomiting, dizziness, headache, and muscle aches [1]. Alcohol is mainly absorbed in the digestive tract, with up to 30% absorbed in the upper gastrointestinal tract and 60% in the small intestine. This absorbed alcohol is metabolized by the liver. The remaining 10% is excreted through one’s breath, urine, and sweat. Absorbed alcohol is oxidized to acetaldehyde by alcohol
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