Enhance dissolution rate and solubility of solid drugs through pharmaceutical deep eutectic solvents

Abstract

Pharmaceutical active ingredients are usually sold in the markets in the form of solid drugs. These drugs are often associated with some problems like polymorphism, bioavailability and low solubility.  In this study, deep eutectic solvents (DESs) are used to change solid drugs into liquids, which may provide a potential solution to these problems. This research describes synthesis and design of pharmaceutical deep eutectic solvents (PDESs) from hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs), which are one of the key parts of medicine improvement. Differential scanning calorimetry (DSC) was used to measure glass transition temperatures for the prepared PDESs and fourier transform infrared spectroscopy (FT-IR) was utilized to clarify hydrogen bond formation between HBDs and HBAs. Also, dissolution test apparatus and UV-Vis spectroscopy were used to measure dissolution rate and concentration of the prepared PDESs in this work.