Abstract
The study was done to assess the ameliorative effects of co-administration of methanol extract of Bridelia ferruginea stem bark and diminazene aceturate on trypanosomosis induced testicular and haematological changes in infected male rat. Twenty five male rats were used in the study and assigned into five groups (n=5). Trypanosoma brucei was inoculated into Groups 1, 2, 3 and 4 rats except Group 5. Diminazene aceturate (7 mg/kg) was administered to group 1. Methanol extract of B. ferruginea (20 mg/kg) was administered to Group 2. Diaminazine aceturate (7 mg/kg) and B. Ferruginea (20 mg/kg) were administered to Group 3. The infected and untreated rats constituted Group 4. The normal control was Group 5. Parameters assessed were weight of the testicles, testicular sperm and epididymal sperm counts, packed cell volume, haemoglobin concentration and red blood and white blood cell counts. At the end of the experiment, there were significant increases in the testicular sperm (56.40±4.55) and epididymal sperm counts (24.34 ± 0.5) of group 3 compared to Group 2 – testicular sperm reserve (51.34 ± 6.19), epididymal sperm reserve (19.38 ± 4.14) and Group 1 – testicular sperm reserve (54.01± 6.92), epididymal sperm reserve (20 ± 5.79). The WBC was significantly higher in infected untreated (13. 70 ± 5.15) compared to Groups 1 (10.96 ± 1.21), 2 (10.36 ± 2.09) and 3 (10.55 ± 0.49). The results above showed that co-administration of diminazene aceturate and B. ferruginea extract produced optimum ameliorative effect. Key words: Bridelia ferruginea, diminazene aceturate, testicular changes, trypanosomosis.
Highlights
Trypanosomosis is a clinical disease caused by the protozoa, Trypanosoma
The study was done to assess the ameliorative effects of co-administration of methanol extract of Bridelia ferruginea stem bark and diminazene aceturate on trypanosomosis induced testicular and haematological changes in infected male rat
Diminazene aceturate is a common trypanocide used in the management of animal trypanosomosis in Africa (Olajide et al, 1999); chemotherapy has been associated with resistance, relapse, cross resistance and toxicity of drugs to animals
Summary
Trypanosomosis is a clinical disease caused by the protozoa, Trypanosoma. Glossina species transmit the disease. Two groups of trypanosomes affect both man and animals They are Trypanosoma congolense and Trypanosoma vivax (haematic group) and Trypanosoma brucei,. The species commonly affecting livestock are T. vivax, T. congolense and T. brucei causing sleeping sickness in animals (Steverding, 2008). It has been reported that trypanosomosis reduces reproductive function in male animals. It causes decrease in libido, delayed maturity, degeneration of the testicles leading to production of poor quality spermatozoa in male animals (Sekoni, 1994). Diminazene aceturate is a common trypanocide used in the management of animal trypanosomosis in Africa (Olajide et al, 1999); chemotherapy has been associated with resistance, relapse, cross resistance and toxicity of drugs to animals. Despite the advances in various aspects of trypanosomosis therapy, therapy has not been able to protect the testicular and haematological changes in treated animals; there is the need to develop a therapy regimen that will solve the problems of testicular and haematological disorders associated with trypanosomosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
