Abstract
Toxoplasmosis is an anthropozoonosis of medical and veterinary importance, due to the protozoan Toxoplasma gondii. Oocysts shed by felids play a key role in parasite transmission as they contaminate meat-producing animals, vegetables and water consumed later by humans. This study tried to study the effectiveness of spiramycin in the treatment of toxoplasmosis in the laboratory of the Abass NDAO Hospital’s (CHAN) in human immunodeficiency virus (HIV)-positive women (82 cases) using the enzyme immunoassay method solid phase (EIA). It reveals a negativity of IgM antibodies and progressive regression of IgG antibodies more visible in three women as high (between 50 and 100 International Units (IU)/ml) and in three other unreliable in the first immunoglobin M (IgM) serology by a seroconversion at the second serology with a stabilization of immunoglobin (IgG) 10 IU/ml. The effectiveness of current treatment has been demonstrated by low return rate IgG antibodies to 10 IU/ml in those who received 3 million IU of Rovamycin at a dose of 2 tablets for day to one month. These first results need to be followed by more extensive investigations. Key words: Prevalence, treatment, toxoplasmosis, Toxoplasma gondii.
Highlights
Toxoplasma gondii is the agent of a cosmopolitan anthropozoonosis: toxoplasmosis
The study population consisted of 82 toxoplasmosis serology-positive women at the laboratory of the Abass NDAO Hospital
They all received treatment and met free serological tests. 82 patients were infected in the first serology (S1): 38 (46.34%) with either a recent active infection is an old chronic infection; 29 (35.36%) is a recent active infection; 10 (12.2%) had a recent infection or early non-specific immunoglobin M (IgM) antibodies fixation; 4 (4.87%) had a former active or chronic infection and one (1.22%) had a recent infection or early attachment non-specific IgM antibodies (Table 1)
Summary
Toxoplasma gondii is the agent of a cosmopolitan anthropozoonosis: toxoplasmosis. This intracellular parasite maintains an optional heteroxenous cycle between cats (definitive hosts) and other warm-blooded animals (intermediate hosts).Toxoplasmosis is almost always asymptomatic but can be severe in immunocompromised individual or after congenital transmission. Toxoplasma gondii is the agent of a cosmopolitan anthropozoonosis: toxoplasmosis. This intracellular parasite maintains an optional heteroxenous cycle between cats (definitive hosts) and other warm-blooded animals (intermediate hosts). Toxoplasmosis is almost always asymptomatic but can be severe in immunocompromised individual or after congenital transmission. The medical and veterinary importance of toxoplasmosis drives for 50 years numerous epidemiological studies to identify the reservoirs and modes of transmission of the parasite (Try et al, 2000). The consumption of raw or undercooked meat containing cysts of the parasite and the ingestion of oocysts with fruits contaminated with faeces of cats are the two main modes of contamination. The consumption of water contaminated with oocysts was identified as a risk factor for toxoplasmosis in Brazil (Bahia - Oliveira et al, 2003).
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