Abstract
Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and long-term complications affecting the eyes, nerves, blood vessels, skin and kidneys. Increased glycation of proteins and accumulation of advanced glycation endproducts (AGEPs) have been implicated in the pathogenesis of diabetic complications. Glycation and AGEP formation are also accompanied by the formation of free radicals via autoxidation of glucose and glycated proteins. Since this plant Eremurus persicus is used as an antidiabetic agent in Iranian traditional medicine, we were prompted to evaluate the antiglycation activity of this species. Here, we reported the isolation of a known compound, 5,6,7- trimethoxy-coumarinfor the first time for the antiglycation properties of this plant. Key words : Antiglycation, Eremurus persicus, 5,6,7-trimethoxy-coumarin.
Highlights
Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and long-term complications affecting the eyes, nerves, blood vessels, skin and kidneys
Glycation and advanced glycation endproducts (AGEPs) formation are accompanied by the formation of free radicals via autoxidation of glucose and glycated proteins
Diabetes mellitus is an endocrine disorder characterized by chronic hyperglycemia which results to a deficiency or resistance to insulin
Summary
Diabetes mellitus is an endocrine disorder characterized by chronic hyperglycemia which results to a deficiency or resistance to insulin. Increased glycation of proteins and accumulation of advanced glycation endproducts (AGEPs) have been implicated in the pathogenesis of diabetic complications. Since this plant Eremurus persicus is used as an antidiabetic agent in Iranian traditional medicine, we were prompted to evaluate the antiglycation activity of this species.
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