Abstract
Grapefruit (Citrus Paradise, family Rutaceae) is a citrus fruit that is low in calories and rich in dietary fibers. Sibutramine (Sibutramine hydrochloride monohydrate) is an anti-obesity drug that enhances satiety. The effect of grapefruit juice and sibutramine on body weight and neurotransmitters controlling appetite was investigated in obese rats. Rats were assigned to two dietary groups for 3 weeks; control group (n=6) was fed commercial standard pellets diet and obese group (n=24) was fed cafeteria diet (hypercaloric diet consisting of highly palatable food). The effect of sibutramine and grapefruit juice was studied on obese rats. Statistical difference and interactions were evaluated through one-way analysis of variance test (one-way ANOVA) followed by Dunnett’s test was used for means of different groups. For all statistical tests done, a 0.05 level of probability was used as the criterion for significance. Grapefruit juice produced its weight reduction effect after 1 week of administration and lasted till the end of the experiment and did not affect brain neurotransmitters. Sibutramine produced its weight reduction effect after 1 week of administration and lasted for only 2 weeks and produced an increase in brain noradrenaline while grapefruit juice produced its effect from the first week till the end of the study. It can be concluded that grapefruit juice is better than sibutramine since its effect lasted till the end of the experiment and also did not affect brain noradrenaline. Key words: Obesity, sibutramine, grapefruit juice, cafeteria diet.
Highlights
IntroductionObesity represents one of the most serious global health issues that have increased to the extent that it could be considered pandemic (Abolfotouh et al, 2008)
Obesity represents one of the most serious global health issues that have increased to the extent that it could be considered pandemic (Abolfotouh et al, 2008).Obesity has reached epidemic proportions globally (WHO, 2003)
The aim of this work was to study the effect of grapefruit juice and sibutramine on obesity induced by cafeteria diet in rats
Summary
Obesity represents one of the most serious global health issues that have increased to the extent that it could be considered pandemic (Abolfotouh et al, 2008). Obesity has reached epidemic proportions globally (WHO, 2003). A recent report from the World Health. Organization estimated that approximately 500 million individuals are obese while 1.5 billion are overweight worldwide (WHO, 2011). Obesity occurs through a longstanding imbalance between energy intake and energy expenditure, influenced by a complex biologic system that regulates appetite (Wilding, 2011). Overweight and obesity joined underweight, malnutrition, and infectious diseases as major health problems threatening the developing world (Hossain et al, 2007). At least 2.6 million people each year die as a result of being overweight or obese
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