Abstract
The effects of extracts of Digitalis purpurea L., Sambucus nigra L., Thuja occidentalis L., Urtica urens L., Arctostaphylos uva-ursi L. and Apis mellifica L. were analyzed in vivo in mice. The analysis of neuro-pharmacologiacl activity was recorded at different doses such as 100, 300 and 500 mg/kg and compared with control and standard drug, Diazepam. The tested extracts exhibited significant neuro-pharmacological activities in open field, dip cage, light and dark, cage cross and forced swimming activities. Our research supports the safe and effective use of the extracts in low doses. Key words: Neuro-pharmacological, open field activity, dip cage activity, light and dark activity, cage cross activity, forced swimming test.
Highlights
This study was carried out on Apis mellifica L., Digitalis purpurea L., Sambucus nigra L., Thuja occidentalis L., Urtica urens L., Arctostaphylos uva−ursi L., with the objective to explore the neuro-pharmacological activities of these drugs which are in current use of cardiac diseases, skin problems, urinary tract infection, gastro-intestinal tract disorders, allergic conditions, maintaining normal blood pressure, in the removal of kidney stone etc
The neuro-pharmacological effects were observed at the dose of 100 mg/kg of A. mellifica extract as follows; in open field activity (28 ± 2.84) counts in 30 min were observed, while in head dip test, the mice dipped head (13.33 ± 2.61) times
The neuro-pharmacological effects were observed at the dose of 100 mg/kg of U. urens extract in case of open field activity, 85.83 ± 3.53 counts in 30 min and cage cross 67.5 ± 3.15 times activity
Summary
This study was carried out on Apis mellifica L., Digitalis purpurea L., Sambucus nigra L., Thuja occidentalis L., Urtica urens L., Arctostaphylos uva−ursi L., with the objective to explore the neuro-pharmacological activities of these drugs which are in current use of cardiac diseases, skin problems (dermatitis), urinary tract infection, gastro-intestinal tract disorders, allergic conditions, maintaining normal blood pressure, in the removal of kidney stone etc. These activities are reported by different researchers (Klass et al, 2002; Navarro et al, 2000; Bisset and Wichtl, 2001; Chang et al, 2000; Chrubasik et al, 2007; Matsuda et al, 1992)
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