Abstract
Persea duthiei plant crude extracts were subjected to evaluation for antibacterial and antifungal activities. For antibacterial activities, seven bacterial strains; Escherichia coli(NCTC 10418), Pseudomonas aeruginosa, Klebsiella pneumonia (ATCC 700603),Staphylococcus epidermidis (NCTC 11047), Staphylococcus aureus, methicillin resistant S. aureus (MRSA: NCTC 13143) and Salmonella were used. All fractions of the plant were completely inactive on three bacterial strains: E. coli, P. aeruginosa, and S. epidermidis, which were used in the antibacterial assays. Water fraction showed promising activity against MRSA. Ethyl acetate, chloroform, ethanol, and n-Hexane extracts showed activity againstSalmonella, MRSA and Staphylococcus aureus. n-Hexane extract also showed activity against Klebsiella up to some extent. For antifungal activities, four fungal strains: Aspergillus flavus, Fusarium solani, Aspergillus fumigatus and Aspergillus niger were subjected to crude extract. Water fraction was found highly active against F. solani and A. niger, while it showed good activity against other strains. Ethyl acetate fraction was prominent against F. solani andA. niger. Chloroform fraction showed significant activity against F. solani. Phytochemical analysis was also performed using the literature methods. Key words: Persea duthiei, antimicrobial activity, crude extracts.
Highlights
Phyto-remedies have shown great promise in the treatment of intractable infectious diseases including opportunistic AIDS infections (Loiy et al, 2011)
All fractions of the plant were completely inactive on three bacterial strains: E. coli, P. aeruginosa, and S. epidermidis, which were used in the antibacterial assays
Water fraction was found highly active against F. solani and A. niger, while it showed good activity against other strains
Summary
Phyto-remedies have shown great promise in the treatment of intractable infectious diseases including opportunistic AIDS infections (Loiy et al, 2011). Lack of development of new antimicrobial agents in the last decades associated with their misuse led to the emergence of multiresistant microorganisms (Lai et al, 2012). The compounds that can either inhibit the growth of pathogens or kill them and have no or least toxicity to host cells are considered candidates for developing new antimicrobial drugs (Maher, 2011). Persea duthiei is a small or medium-sized evergreen tree widely distributed around Nainital, at altitude of 2500 m. The root stocks are acrid, bitter, pungent, heating, and astringent and are generally used in inflammation, asthma, pain, foul breath, bronchitis, vomiting, and in blood disease (Padalia et al, 2009). Keeping in mind the importance of P. duthiei, it was selected for the present study
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