Abstract
Adequate studies have been done using proton pump inhibitors and H2-receptor antagonist and only few studies for cyto-protective and gastric acid secretions have been done in Nigeria. Therefore this work studied the cyto-protective and gastric acid secretory effects of rabeprazole, ranitidine, omeprazole and cimetidine in wistar rats. 28 male wistar rats of weights 300 to 400 g were recruited and randomly divided into seven experimental groups of 4 rats each. Ulcers were induced via oral administration of a mixture acid alcohol (Ethanol and HCl). Group A: Ulcer alone; Group B: 20 mg/kg Rabeprazole + Ulcer; Group C: 20 mg/kg Rabeprazole + 20 mg/kg Ranitidine + Ulcer. Group D: Normal control group received clean drinking water ad libitium. Group E: 20 mg/kg Omeprazole + Ulcer. Group F: 20 mg/kg ranitidine + ulcer. Group G: 100 mg/kg cimetidine + ulcer. At the end of the treatment and induction, volume of gastric acid secreted, pH values, Ulcer index, stomach and body weights were analyzed statistically. There were significant decrease (P<0.05) in the volume of gastric acid secreted for the groups that received the ranitidine and rabeprazole compared to group A (ulcer alone). The pH values of the groups that received the proton pump inhibitors were neutralized at the end of the experiment which shows a better cyto-protective effects of the drugs and there were significant differences (P<0.05) among those groups E, F and G compared to group A. The animals with lesser stomach weights have more ulcers index compared to those with higher stomach weights. This research showed that groups treated with a combination of rabeprazole and ranitidine has a better potency for the management of gastric ulcer patients. Key words: Ulcer, acid-alcohol, Rabeprazole, Ranitidine, Omeprazole, Ranitidine, Wistar rats.  
Highlights
Gastric ulcer is a deep defect in the gastric wall penetrating the entire mucosal thickness and muscaris mucosa (Adeniyi et al, 2016)
It has been reported that animals with smaller stomach weight has more ulcers than those with higher stomach weight and there is a correlation as depicted by the ulcer index table and that of the stomach weight
Results were expressed as Mean± Standard Error of Mean; (n=4), Values with superscripts showed a statistical significant difference; *P
Summary
Gastric ulcer is a deep defect in the gastric (stomach) wall penetrating the entire mucosal thickness and muscaris mucosa (Adeniyi et al, 2016). It is the most common prevalent gastrointestinal disorder ever known accounting 15 mortalities from 15,000 complications yearly in the world. An ulcer in the gastrointestinal tract is a deep necrotic region penetrating the entire mucosal thickness and muscularis mucosae. Ulcer healing is an active process of filling the mucosal defect with proliferating and migrating epithelial and tissue cells. Epithelial cells proliferate and migrate unto the granulation tissue to cover (repitheliliaze) the ulcer and invade granulation tissue to reconstruct the glandular structures within the ulcer scar. Colloidal bismuth and aluminum containing antacids (Yuan et al, 2015).Gastric ulcers have long been rated as one of the most common diseases affecting humans and young people in particular (Saad et al, 2016)
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