Abstract
Urinary Tract Infection (UTI) is one of the commonest infectious disease in pregnancy, and in pregnancy we have very limited number of antibiotics to treat the UTI. This study was conducted on 151 patients who attended the gynecology clinic during the study period. Nineteen UTI proven cases of UTI were studied for prevalence of microorganism and sensitivity pattern against different antibiotics. Among the bacteria isolated, Escherichia coli (73.68%) and Staphylococcus aureus (10.52%) were the most prevalent Gram negative and Gram positive bacteria respectively. To know the resistance pattern of microorganism we used commercially available discs of different antibiotics. Gram negative bacteria showed more resistance as compared to Gram positive one. It is observed that the most effective antibiotic for Gram negative isolates is Ceftriaxone (87.5%), followed by Amoxicillin + Clavulanic acid (81.25%), Amikacin (75%), Cefuroxime (75%), Cefixime (68.75%) and Mezlocillin (62.5%). For the Gram positive bacteria, Ceftriaxone, Amikacin and Amoxicillin + Clavulanic acid were the most effective antimicrobials (100%). Multidrug resistance Gram negative bacteria were also tested for Extended-spectrum Beta Lactamase (ESBL), 35.71% of E. coli isolates were ESBL producer. Key words: Urinary tract infection, pregnancy, drug resistance, uropathogens, extended spectrum β-lactamase.
Highlights
Urinary Tract Infections (UTIs) are common and in the clinical practice it is the second most community-acquired infection worldwide (Awaness et al, 2000; Marcus et al, 2005)
We observed that overall prevalence of UTI among the pregnant women is 12.5% which is almost similar to a study conducted in different parts of Saudi Arabia (Al-Sibai et al, 1989)
The pattern may be differing from place to place and time to time, but in most of the studies conducted in different regions of the world, it is observed that E. coli is the most common microorganism causing UTI in pregnancy or clinical practice
Summary
Urinary Tract Infections (UTIs) are common and in the clinical practice it is the second most community-acquired infection worldwide (Awaness et al, 2000; Marcus et al, 2005). UTIs affects all age groups, but due to absence of prostatic secretion, short urethra, easy contamination of urinary tract by fecal bacteria and pregnancy, women are more prone than men (Jido, 2014; Awaness et al, 2000). UTI is one of the most common type infections during pregnancy and after anemia second most common disease (Santos et al, 2011). Due to the physiological change, plasma volume increases and urine concentration decreases during pregnancy.
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