Abstract
Bupleurum species are widely distributed in China and its diversity is of a potential commercial incomes. In this study, five species of the genus Bupleurum were collected in four mountains in North China areas. The saikosaponins a and d (SSa and SSd) roots concentration were determined by high performance liquid chromatography (HPLC) and the results revealed that B. smithii, B. sibiricum and B. scorzonerifolium might be of great interest because of their high SSd content in which the –OH of C-23 is involved in their bioactivity. This study, besides being helpful for medicine quality control, provides an insight of the importance saikosaponins. Especially, SSd might play in the discovery of new drugs against bacterial or viral diseases such as HIV. Key words: Bupleurum spp., Saikosaponins a and d, roots content determination, HPLC.
Highlights
Scientific research into medicinal plants or herbs dates back thousands of years as cultures explored which plants were useful for what conditions and passed information on species, preparation, and dose through the ages
The saikosaponins a and d (SSa and SSd) roots concentration were determined by high performance liquid chromatography (HPLC) and the results revealed that B. smithii, B. sibiricum and B. scorzonerifolium might be of great interest because of their high SSd content in which the –OH of C-23 is involved in their bioactivity
The quantities of saikosaponins a and d were estimated from the curves areas produced by HPLC of each saikosaponin
Summary
Scientific research into medicinal plants or herbs dates back thousands of years as cultures explored which plants were useful for what conditions and passed information on species, preparation, and dose through the ages. This longstanding use, as for Traditional Chinese Medicine (TCM) and European herbal medicine up to the present time, provides an invaluable database on the safety and efficacy of numerous species. Because of the complexity of chemical content and variety of bioactivities, herbal medicine offers the prospect of the kind of "built in” poly-pharmacology that is increasingly apparent for orthodox drugs (Perry and Howes, 2010). Plenty of elements have been considered as important and, most probably, others will be recognized as essential in the future
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