Abstract
An UV spectrophotometric method using simultaneous equation was developed for the simultaneous determination of ranitidine and itopride in a binary mixture. In the proposed method, the signals were measured at 315.0 and 258.0 nm corresponding to absorbance maxima of ranitidine and itopride hydrochloric acid (HCl) in double distilled water, respectively. Linearity range was observed in the concentration range of 2 to 20 µg/ml for both drugs. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 315.0 and 258.0 nm and solving the simultaneous equation. Developed method was applied to laboratory mixture. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. The method was found to be rapid, simple, accurate and precise. Key words: Itopride, simultaneous equation, spectrophotometry, ranitidine.
Highlights
An UV spectrophotometric method using simultaneous equation was developed for the simultaneous determination of ranitidine and itopride in a binary mixture
Ranitidine hydrochloride (RanHCl) is a H2-receptor antagonist which is used as anti-ulcer drug that reduces acid secretion by blocking the histamine receptor type
Itopride hydrochloride (ItoHCl) (Gupta et al, 2004) is a new gastro-prokinetic agent which is used in reflux oesophagaitis (Pillai and Singhvi, 2008)
Summary
Ranitidine hydrochloride (RanHCl) is a H2-receptor antagonist which is used as anti-ulcer drug that reduces acid secretion by blocking the histamine receptor type. The only difference is that it contains furan ring in place of imidazole ring of cimetidine This one is amino alkyl furan derivative. Itopride hydrochloride (ItoHCl) (Gupta et al, 2004) is a new gastro-prokinetic agent which is used in reflux oesophagaitis (Pillai and Singhvi, 2008) These two drugs are natural candidates for combination therapy in the treatment of reflux oesophagitis, dyspepsia, hyperacidity etc. Characterization of formulations like tablets, capsules or microcapsules having this combination of drugs will require simultaneous determination of RanHCl and ItoHCl in aqueous buffer media Because of this reason for determining the concentration of the drugs simultaneously in the acidic dissolution medium, a sensitive, validated, less time consuming and low cost analytical method by UV-spectrophotometry is required to be developed.
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