Abstract
This study investigated the effects of corresponding 11.7 mg/kg body weight and 5.8 mg/kg body weight/day of the tobacco leaves aqueous extract for a period of 20 days on the functions of rats’ brain after extract administration. Nicotiana tabacum is the scientific name of the tobacco plant grown in several countries of the world. It has been used in variables ways such as smoking, snuffing, even chewing, etc. 24 young rats of both sexes were used. They were divided into 3 groups, A, B, C of 8 rats each (Female (n = 4) and male (n = 4)). Group A were given 11.7 mg of the extract per kg body weight, group B 5.8 mg of the extract per kg body weight in 0.5 ml of distilled water per day throughout the 20 experimental days while group C were given equal volume (0.5 ml) of distilled water as well. The rats were sacrificed at day 21 by cervical dislocation and the brains were excised and fixed in formol calcium for 4 days and processed using Haematoxylin and Eosin staining method and Cresyl Fast Violet (CFV) staining technique. There was a statistical significant decrease in the body weight, brain weight and relative brain weight between groups A and B compared to the control group (p < 0.05). There was enlargement of the somata in the group A administered with 11.7 mg/kg B.Wt per day of the extract while those in group B appeared more spindle compared to those cells in group C. Also, the non – homogenous appearance of myelinated neocortex of the neuropil appear clearly in the treated groups compared to control (Figure 3). Therefore, the results suggested that the consumption of the aqueous extract of N. tabacum leaves may alter the normal functions of the brain which may lead to brain dysfunction, despite its “pleasant” effects and also help in reduction in weight gain. Key words : Nicotiana tabacum , cerebrum, frontal lobe, cytoarchitecture, neocortex.
Highlights
The key organ of the nervous system is the brain which is covered with a tough membrane called meninges
This study investigated the effects of corresponding 11.7 mg/kg body weight and 5.8 mg/kg body weight/day of the tobacco leaves aqueous extract for a period of 20 days on the functions of rats’ brain after extract administration
The results suggested that the consumption of the aqueous extract of N. tabacum leaves may alter the normal functions of the brain which may lead to brain dysfunction, despite its “pleasant” effects and help in reduction in weight gain
Summary
The key organ of the nervous system is the brain which is covered with a tough membrane called meninges. The brain floats within the skull in a liquid known as a cerebrospinal fluid (CSF), and it is responsible for coordination of body systems. The frontal lobe is concerned with voluntary motor functions, motivation, foresight planning, memory, mood, emotion, social judgement, and aggression (Salardin, 2001; James, 2002; Standring et al, 2005). Because of this important fact, a structural change that may occur within the frontal lobe (cerebrum) is vital to our health state. The nicotine is the highest and most toxic compound of aqueous extract of tobacco leave and of neurotoxic important (Sas, 1990; Philip, 2002; Penton and Lester, 2009)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.