Abstract
The analysis of chromatographic profiles of the essential oil of Piper mollicomum and Piper rivinoides for Multidimensional gas chromatography (MDGC) allowed the identification of 18 compounds in essential oil of Piper mollicomum (EOPM) and 19 compounds in essential oil of Piper rivinoides (EOPR), being β-ocimene and α-pinene which are the major compounds, respectively. In the test of writhing induced by acetic acid (0.8%) to verify the antinociceptive activity, the EOPM and EOPR at 1 mg/kg showed significant inhibition of writhing of 20.90 and 50.25%, respectively compared to the control. The aim of this study was to evaluate the chemical composition and antinociceptive activity of essential oils from fresh leaves of P. mollicomum (EOPM) and P. rivinoides (EOPR). Key words: Piper mollicomum, Piper rivinoides, multidimensional gas chromatography (MDGC), essential oil, antinociceptive effect.
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