Abstract
Hepatitis B virus (HBV) infections severely threaten the health of the human being. Frequent recombination of HBV within or between genotypes was reported to favor the viral evolution and adaption and the recombination may cause more severe clinical symptoms. In the study, we collected genotype C HBV from five Asian countries and detected their possible recombination events by bioinformatic analysis. There are two main subtypes, C1 and C2, within the C genotypes among the collected data in the study. Subtype C1 is most prevalent in Cambodia, Bangladesh, and China, while C2 is prevalent in Japan, Indonesia, and a small part of China. Three recombination events were detected and verified from C1 genotype HBV from Hong Kong China as demonstrated by recombinant (KJ410515), ranging from 2381 to 1861 nt. Recombinant events were detected and verified by recombination analysis in the study. It is important to filter possible recombinants when using the online-genbank data to do phylogenetic analysis. Key words: Hepatitis B virus, subgenotype C1, genotype C, subgenotype C2, recombinant analysis, HBV Hong Kong, China.
Highlights
Hepatitis B virus (HBV) infection severely threatens the health of the human being
“HBV genotype C complete genome” and “HBV C” and “China” were used as keywords research terms, and the search results were filtered by sequence length from 2800 to 3500 nt and genotype C. 131 complete genome sequence were retrieved from the research records
Molecular Evolutionary Genetics Analysis (MEGA) X ran preliminary multiple sequence alignments and the RDP4 program performed our recombinant analysis of full-sequences and recombination analysis
Summary
Hepatitis B virus (HBV) infection severely threatens the health of the human being. Thirty percent of the infected person even died from HBV-related liver disease. Due to the lack of proofreading activity of viral polymerase during the reverse transcription step of genome replication, HBV genetic variability is high and leads to differences in nucleotide sequence (Arauz-Ruiz et al, 2002; Norder et al, 1994; Okamoto et al, 1988; Stuyver et al, 2000). Eight genotypes (A-H) have been established based on the 7.5% inter-ethnic differences in the entire nucleotide sequence (Arauz-Ruiz et al, 2002; Norder et al, 1994; Okamoto et al, 1988; Stuyver et al, 2000)
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