Abstract
After removal of lens from eye of Rana cyanophlyctis, the pigmented epithelial cells of dorsal iris started to proliferate and dedifferentiate and consequently regenerate lens. Vitamin A and ascorbic acid enhanced the percentage lens regeneration not only in young tadpoles but also in froglets. Lens regeneration ability declined with age of animals in both control as well as treated groups. Key words: Rana cyanophlyctis, pigmented epithelial cells, vitamin A, ascorbic acid.
Highlights
Urodele amphibians are unique among vertebrates in their strong ability to regenerate lost part/ parts of body throughout their lives (Ferretti and Geraudie 1998; Wolpert et al, 1998) and in their striking resistance to tumor occurrence (Okamoto, 1987, 1988, 1997; Brockes, 1998)
We proved that pigmented epithelial cells of dorsal iris have intrinsic ability to transdifferentiate into lens
The experiment concerned the study of lens regeneration in young tadpoles, mature tadpoles and froglets of R
Summary
Urodele amphibians are unique among vertebrates in their strong ability to regenerate lost part/ parts of body throughout their lives (Ferretti and Geraudie 1998; Wolpert et al, 1998) and in their striking resistance to tumor occurrence (Okamoto, 1987, 1988, 1997; Brockes, 1998). After lens removals through the pupil of the newt’s eye, pigmented dorsal iris epithelial cells begin to dedifferentiate, proliferate and transdifferentiate into lens cells (Wolff, 1895; Kodama and Eguchi, 1995). It is noteworthy that only the dorsal iris can regenerate a new lens, while the ventral iris never shows such ability. Despite many morphological and biochemical studies on the process of lens regeneration, the difference between dorsal and ventral cells remains to be elucidated (Reyer, 1977; Yamada, 1977). We proved that pigmented epithelial cells of dorsal iris have intrinsic ability to transdifferentiate into lens. Vitamin A and ascorbic acid was found to accelerate the percentage of lens formation from the dorsal iris in in vivo condition
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