Abstract
English
Highlights
Cancer is a leading cause of death world-wide
The epithelial ovarian cancer (EOC) is classified into five types based on their histopathology and includes high grade serous carcinomas; clear cell carcinomas; endometroid carcinomas; clear cell carcinomas and low-grade serous carcinomas [3]
Primary cultures of EOCs and human Wharton's Jelly stem cells (hWJSCs) Primary cultures of EOCs were established from the ovarian surface epithelium
Summary
Cancer is a leading cause of death world-wide. The 2012 cancer statistics estimated about 1638,910 new cancer cases and 577,190 cancer related deaths in the United States [1]. Among the cancers in women, ovarian cancer is the most lethal gynaecological cancer and is associated with high mortality [2]. The epithelial ovarian cancer (EOC) is classified into five types based on their histopathology and includes high grade serous carcinomas; clear cell carcinomas; endometroid carcinomas; clear cell carcinomas and low-grade serous carcinomas [3]. Its subtle onset and absence of symptoms in early stages are associated with poor prognosis and high mortality. Many factors are involved in the pathogenesis of EOCs. Given the cellular heterogeneity and signaling complexities in EOCs, use of standard chemotherapeutic regimen may not be always successful. Given the cellular heterogeneity and signaling complexities in EOCs, use of standard chemotherapeutic regimen may not be always successful This is reflected in the 5 year survival rate which
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