Abstract
Human papilloma-virus (HPV) infection confers 85-90% of the attributable risk for the development of cervical dysplasia. Worldwide and in particular in Nigeria, HPV 16 has been shown as the most prevalent HPV type and it also contributes more to the development of invasive squamous cell carcinoma. Studies have also shown that the prevalence of HPV is higher among HIV-positive women than among HIV-negative women of all age groups. HIV-positive women also have a higher incidence of squamous intra-epithelial lesion (SIL) and invasive cervical cancer. Progression to cervical cancer is also more rapid amongst these patients and often refractory to treatment with high incidence rates. Current screening recommendations for HIV-positive women are accessible and developed in rich countries. The best strategy for screening infected women in poorer nations where human immunodeficiency virus (HIV) is rampant remains uncertain and challenging. Key words: Human papilloma-virus (HPV), human immunodeficiency virus (HIV), cervical dysplasia, invasive squamous cell carcinoma.
Highlights
Historical perspectiveHistorically, Papillomavirus has co-evolved with vertebrates
21 women, initially presented with a low grade squamous intraepithelial lesion (SIL). These results suggested that HAART may result in reduced prevalence of cervical SIL despite none clearance of Human papilloma-virus (HPV)
According another study, carried out to evaluate the effect of HAART on HPV clearance and cervical cytology, among human immunodeficiency virus (HIV)-positive women with cervical squamous intraepithelial lesions, HAART was associated with an increased likelihood of HPV clearance unlike in HIV-positive women with normal cytology or atypical squamous cells of undetermined significance (Paramsothy et al, 2009)
Summary
Human papilloma virus and cervical neoplasia in HIV positive women: A non systematic review. Human papilloma-virus (HPV) infection confers 85-90% of the attributable risk for the development of cervical dysplasia. Worldwide and in particular in Nigeria, HPV 16 has been shown as the most prevalent HPV type and it contributes more to the development of invasive squamous cell carcinoma. Studies have shown that the prevalence of HPV is higher among HIV-positive women than among HIV-negative women of all age groups. HIV-positive women have a higher incidence of squamous intra-epithelial lesion (SIL) and invasive cervical cancer. Current screening recommendations for HIV-positive women are accessible and developed in rich countries. The best strategy for screening infected women in poorer nations where human immunodeficiency virus (HIV) is rampant remains uncertain and challenging
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