Abstract
The aim of this study was to investigate the medication status of 508 patients with type IIdiabetes admitted to Huashan Hospital, and to guide their clinical medication. The data of the 508 patients with type II diabetes who were admitted to Huashan Hospital between July, 2010 and December, 2010 were collected and analyzed. In 508 patients, acarbose was the most frequently prescribed medication (n = 337, 66.34%), the highest frequency of acarbose was 66.34% (n = 337). Metformin which belongs to the biguanide group accounted for 20.28%. Pioglitazone which belongs to thiazolidinedione group had the lowest frequency of use, and was only 1.38% (n = 7), and patients were often treated with combination therapy (n = 194, 38.18 %). A total of 431 patients (85%) had chronic diabetes complications (state which ones: macro or micro vascular complications). Among the diabetic patients, age groups in 40 to 80 had the highest probability of illness and the incidence rate increases with age; therefore, this group should take regular medical examinations to prevent diabetes induced complications. In the choice of medication, prescription drugs like acarbose and other α-glucosidase inhibitors, at the same time, combined medication with pancreatic kinionogenase are preferred. Enteric-coated tablets or other drugs to treat high blood pressure diabetes, heart disease, nervous system damage and other complications are also recommended. Key words: Type II diabetes, combined medication, age related, complication, biguanide.
Highlights
Diabetes is a chronic metabolic disorder induced by multiple pathogenic factors, if blood glucose is not well controlled, complications will occur, resulting in the lesions of failure of kidney, eye, feet and other parts which cannot be cured
Enteric-coated tablets or other drugs to treat high blood pressure diabetes, heart disease, nervous system damage and other complications are recommended
Acarbose is the most frequently used hypoglycemic agent, its mechanism of action is to inhibit the activity of intestinal-type cells, αglucosidase, and to delay the hydrolysis of carbohydrates, production of glucose, as well as the absorption of glucose
Summary
Diabetes is a chronic metabolic disorder induced by multiple pathogenic factors, if blood glucose is not well controlled, complications will occur, resulting in the lesions of failure of kidney, eye, feet and other parts which cannot be cured. Taking into account the weight loss, gastrointestinal reactions, and other factors among some patients, if they are not suitable for using metformin, the other drugs should be taken into consideration (Chinese Diabetes Society, 2010). Patients with type II diabetes are usually treated with oral administration of hypoglycemic agents. To investigate the clinical application status of such drugs, data of 508 cases of patients with type II diabetes in our hospital were collected and retrospectively analyzed. Calcium antagonists and angiotensinconverting enzyme inhibitors are beneficial in diabetes mellitus complicated with hypertension, both types of drugs can reduce left ventricular hypertrophy and enable short-term reduction of proteinuria, but a conclusive result is still difficult to be obtained from long-term followup (Hao-lin and Nan-sen, 1999). Several studies have shown that angiotensin-converting enzyme inhibitors can lower blood pressure, and reduce blood glucose and improve glucose tolerance (Baron et al, 1993)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
