Abstract
Only one study has reported on the medicinal properties of Cordia platythyrsa (C. platythyrsa) though it is used in African traditional medicine for treatment of fever and pain. The current study aimed at investigating the analgesic and anti-inflammatory properties of C. platythyrsa using various animal models: writhing test, tail flick, thermal hyperalgesia, mechanically induced-pain, formalin-induced pain and carrageenan-induced inflammation tests. Like aspirin, the two doses of plant extracts used inhibited acetic acid-induced pain though these effects were weaker than the effects of morphine. Although, the plant extract significantly (p<0.01) inhibited thermal pain, its effects were less significant compared to morphine. Celecoxib (10 mg/kg) and plant extract (100 mg/kg) significantly inhibited thermal hyperalgesia compared to indomethacin. On the other hand, both doses of plant extract significantly increased mechanical pain thresholds 30 and 90 min post treatment. The plant extract (150 mg/kg) inhibited both the neurogenic and inflammatory pain phases of formalin-induced pain as well as carrageenan-induced inflammation. This study is the first to show that C. platythyrsa has analgesic and anti-inflammatory properties. Key words: Analgesia, pain, writhing, formalin, thermal hyperalgia.
Highlights
Cordia platythyrsa (Baker) is a boragenaceae which grows up to 30 m high and about 3 m in girth
One study has reported on the medicinal properties of Cordia platythyrsa (C. platythyrsa) though it is used in African traditional medicine for treatment of fever and pain
The analgesic effect of aspirin was weaker than the effect of morphine which was significantly better than the effect of aspirin and C. platythyrsa, respectively (Table 1)
Summary
Cordia platythyrsa (Baker) is a boragenaceae which grows up to 30 m high and about 3 m in girth. It is commonly found in secondary forests stretching from Sierra Leone to Congo. Its wood is used for furniture and building. In fishing communities, it is the wood of choice for canoe manufacturing due to its fungal and insect resistant properties (Burkil, 2004). Some plants from the Cordia genus have been shown to have anti-inflammatory, antimicrobial and anti-snake venom activities (Sertie, 2005; Kloucek, 2007; Ticli, 2008). A new dioxime (cordioxime) with gamma-lactam activity was isolated and characterized from extracts of C. platythyrsa (Christelle et al, 2011)
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