Abstract
Tea from Camellia sinensis (L.) Kuntze has long been used in herb medicine and recognized to possess anti-inflammative effects. The aim of the current study was to evaluate the therapeutic effects of green tea polyphenols in treatment of pharyngitis in human subjects. The clinical study was carried out as a randomized, double-blind, parallel-group comparative trial. It was found that the integral scores of all the observed individual clinical signs and symptoms were decreased significantly from pre-treatment to post-treatment (P<0.05) in both green tea polyphenols treatment and the control. Therapeutic effects assessment showed that the decrease in the total integral scores in the green tea polyphenols group was more significant (P<0.05) than in the control medicine group and that green tea polyphenols had a more prominent efficacy (P<0.05) in eliminating pharyngodynia in pharyngitis patients. Green tea polyphenols demonstrated high total effective rate in the pharyngitis treatment (n = 60, 96.67%). Neither adverse events nor abnormal observation in vital signs were found throughout the study. It can be concluded that green tea polyphenols can be used as a reliable and effective phytochemical in the treatment of pharyngitis. Key words: Green tea polyphenols, clinical evaluation, pharyngitis, human subjects.
Highlights
Pharyngitis is one of the most common diseases encountered by physicians and is especially a big problem troubles those who have to use laryngopharynx and vocal holds frequently in their professional activities like teachers, singers and broadcasters (Matthys et al, 2007; Bisno et al, 2002; Huang, 2003)
Changes in the scores of pharyngitis signs and symptoms from the pre-treatment patients and the post-treatment participants of the study were compared between the green tea polyphenols group and the control medicine group (Table 2)
It was found that both green tea polyphenols and the control medicine had an efficient efficacy in the treatment of pharyngisits in human subjects who visited hospital doctors as seen in the changes in integral scores of all the observed individual signs and symptoms between pre-treatment and post-treatment (P
Summary
Pharyngitis is one of the most common diseases encountered by physicians and is especially a big problem troubles those who have to use laryngopharynx and vocal holds frequently in their professional activities like teachers, singers and broadcasters (Matthys et al, 2007; Bisno et al, 2002; Huang, 2003) This condition is most often caused by direct infection of the pharynx by various viruses or bacteria (Bisno et al, 2002), among which group A beta-hemolytic streptococcus (GABHS) accounts for about 15 to 30% cases in children and 5 to 15% cases in adults (Bisno et al, 2002; Ruppert, 1996; Matthys et al, 2007). Green tea contains catechins in higher quantities than black tea or Oolong tea
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