Abstract
The fruit goji berry of Lyciumbarbarym, a traditional Chinese herbal medicine, has been widely used in healthy diets due to its potential role in the prevention of chronic diseases. We studied the effects ofroridin A toxin in male rat liver and their amelioration by goji extract. Thirtymale adult albino rats were divided into three groups (10 rats each). Group 1 (Control group) was given only the solvent(DMSO) of roridin A. Group 2 was administered a single dose (0.6 mg/ kg) of rordin A mycotoxin (dissolved in 1% DMSO) for one week. Group 3 was treated prophylactically with goji extract (5 mg/kg) using gastric tube daily for 6 days and left for one week. Roridin A showed a highly significant increase in serum levels of cholesterol, triglycerides and significant increase inglucose, total antioxidants and tumor necrosis factor (TNF). There was significant decrease in serum ferritin level. On the other hand, administration of goji along with rordin A showed a reduction in the above mentioned factors and elevation inferritin level. Histopathological changes in the rat liver coincided with the above biochemical changes. In conclusion; the treatment of rats with goji extract ameliorated the adverse effects of rordin A. Thus, gojimay be used asan antioxidant for certain toxins.
Highlights
Mycotoxins, by-products of fungal metabolism have been implicated as causative agents of adversehealth effects in humans and animals that have consumed fungus-infected agricultural products[1,2]
Trichothecenesmycotoxins were conveniently divided into two structure types: (1) Simple, e.g., T-2 toxin, diacetoxyscirpenol (DAS), verrucarol, DON, etc.; and (2) Macrocyclic, e.g., verrucarin A, B, J androridin A, D, E, etc. (Figure 1.2)
The total antioxidant increased in roridin a groupcompared to the control
Summary
Mycotoxins, by-products of fungal metabolism have been implicated as causative agents of adversehealth effects in humans and animals that have consumed fungus-infected agricultural products[1,2]. Group 3: Goji extract (5.0 mg/kg)[16] using gastric tube for 6 days daily the animals treated with roridin A and left for one week. Significant increase in glucose and TNF levels (Figures 9 and 10).
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