Abstract
The ethanol and aqueous extracts of the dried stem bark of the plant Crataeva nurvala Buch-Hum (Capparidaceae) have been found to possess significant anti-fertility effects in rats. Both ethanol and aqueous extracts exhibited partial and complete resorption of implants at 300 and 600 mg/kg b.wt dose levels, respectively. In estrogenic activity study, both the extracts increased uterine weight and caused opening and cornification of vagina in immature rats. The present work justifies its effectiveness in preventing pregnancy in all rats at dose levels. Key words: Anti-fertility, anti-implantation, aqueous and ethanol extracts, Crataeva nurvala.
Highlights
The genus Crataeva (Capparidaceae) is named in honor of the Greek botanist Crataevas
The results clearly showed that both extracts possess anti-fertility effect in a dose-depended manner (Table 1)
The ethanol extract is found to be more active than the aqueous extract
Summary
The genus Crataeva (Capparidaceae) is named in honor of the Greek botanist Crataevas. Crataeva nurvala is commonly known as barna and varuna (Bhattacharjee, 1998) and distributed, throughout India and tropical regions of the world wild or cultivated (Kirtikar and Basu, 1984) It is found along streams and in dry, deep boulder formations in sub Himalayan tract (Agarwal, 1997). It is useful as a laxative, demulcent, stomachic, and blood diseases and is reported to cure disorders of urinary organs (Drury, 1978). It is very useful as antiinflammatory drug and act as a good contraceptive for women. The present work was undertaken to substantiate the folklore claims in a scientific manner using animal models
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