Abstract
This study aims to prepare a novel curcumin ethosomes and investigate its properties as a drug delivery system of curcumin. A new modified method combining thin-film hydration and ultrasound was used to prepare ethosomes. Particle size was determined using Mastersizer 3000 laser diffraction analyzer. Average particle size was calculated based on the measurements of five different batches of ethosomes. Free curcumin was isolated by ultracentrifugation to determine the entrapment efficiency. High performance liquid chromatography (HPLC) was performed to determine the concentration of curcumin. The average particle size of curcumin ethosomes decreased with the increase of ethanol concentrations, whereas it increased with the increase of phospholipid concentration. The entrapment efficacy increased with the increase of ethanol and phospholipids concentration. The particle size of the curcumin ethosomes decreased with the increase of ethanol concentration, and increased with the increase of phospholipids contents. The concentration of ethanol and phospholipids showed a positive impact on entrapment efficiency. Finally, curcumin ethosomes showed high entrapment efficiency and good percutaneous permeability. Key words: Ethosomes, curcumin, liposome, high performance liquid chromatography (HPLC).
Highlights
IntroductionCurcumin (diferuloylmethane), a phenolic compound extracted from the root of Curcuma longa, has been widely used as a spice and coloring agent in food industry
Curcumin, a phenolic compound extracted from the root of Curcuma longa, has been widely used as a spice and coloring agent in food industry
A new type of liposome carrier in drug delivery system to emerge in recent years, showed characteristics of high deformability, high entrapment efficiency and percutaneous permeability through the keratoderma barrier
Summary
Curcumin (diferuloylmethane), a phenolic compound extracted from the root of Curcuma longa, has been widely used as a spice and coloring agent in food industry. Curcumin showed anti-tumor, anti-oxidant, immunomodulatory, enhancing of apoptosis process, and antiangiogenic properties (Schaffer et al, 2011). It has been reported as a mediator of chemo-resistance and radio-resistance (BarSeal et al, 2010). Ethosome showed more stable structure and quality which can promote the percutaneous drug absorption, increase drug storage in the skin cells and drug mobility to the cells. It has the characteristics of prolonged action and avirulent. It has been considered as an important drug carrier (Fang et al, 2009; de la Presa et al, 2009)
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