Abstract
Alhagi maurorum Medik (Fabaceae) is the single species of genus Alhagi found in Iraq, locally known as Aqual. Various studies have shown A. maurorum used in folk medicines. However, its potential health benefits have not been studied in details. Methanol extracts ofA. maurorum from the aerial part were screened for total phenolic and flavonoids contents, antioxidant, antimicrobial and cytotoxic activities. The total phenolic and total flavonoids contents were assessed by Folin–Ciocalteu and aluminum nitrate methods, respectively. Antioxidant properties were measured by diphenyl-1-picrylhydrazyl (DPPH), linoleic acid peroxidation and xanthine oxidase. Antimicrobial activity against six microorganisms was tested using disc diffusion method and cytoxicity test was carried out using methyl thiazolyl tetrazolium (MTT) on the human leukemia cell line (HL-60). The antioxidant properties and total phenolic contents of the leaves were higher than those of the flowers. Antimicrobial activities were characterized by inhibition zones and minimum inhibition concentration (MIC) ranged between 58.0-80.7 and 60.4-84.0 µg mL-1, respectively. Leaves and flowers extract induced inhibitory effect against the proliferation of HL-60 cells and IC50 was 16.0 and 22.0 µg mL-1, respectively. The antimicrobial and cytotoxicity of extracts seemed to be positively correlated with their antioxidant potentials.The present findings indicated that leaves and flowers extracts are highly cytotoxic to HL-60 cells, and leaves extract was more potent in this regard. The present study suggests that A. maurorum may be used as possible natural antioxidant, antimicrobial, and an effective therapeutic agent in the management of acute promyelocytic leukemia. Key words: Alhagi maurorum, phenolic content, antioxidant, antimicrobial, cytotoxic
Highlights
Natural products perform various functions, and many of them have interesting and useful biological activities (Harvey, 1999)
Antimicrobial activity against six microorganisms was tested using disc diffusion method and cytoxicity test was carried out using methyl thiazolyl tetrazolium (MTT) on the human leukemia cell line (HL-60)
The present study suggests that A. maurorum may be used as possible natural antioxidant, antimicrobial, and an effective therapeutic agent in the management of acute promyelocytic leukemia
Summary
Natural products perform various functions, and many of them have interesting and useful biological activities (Harvey, 1999). There are more than 35,000 plant species being used in various human cultures around the world for medicinal purpose. Researchers are increasingly turning their attention to natural products looking for new leads to develop better drugs against cancer, as well as viral and microbial infections (Hoffmann et al, 1993; Harvey, 1999; Srinivasan et al, 2001). Use of herbal medicine in Asia represents a long history of human interactions with the environment. Plants used in traditional medicine contain a wide range of ingredients that can be used to treat chronic as well as infectious diseases. A vast knowledge of how to use the plants accumulated in areas where the use of plants is still of great importance (Diallo et al, 1999)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
